Hypersalivation was the most frequent abnormal clinical observation related to treatment with ITRAFUNGOL and the incidence increased with the higher doses. Mild elevations in ALT were sporadically noted in all groups; however, the number of affected cats increased with the higher doses (two cats in the control group, two cats in the 1X group, three cats in the 3X group, and four cats in the 5X group). Other infrequent adverse reactions included less than 3 cases each of somnolence, depression, and increased salivation. Treating your Yard for Fleas and Ticks. However, after repeated daily doses of itraconazole oral solution at 5 mg/kg for one week, the hydroxy-itraconazole CEffectiveness was demonstrated using ITRAFUNGOL (itraconazole oral solution) in a masked, placebo controlled laboratory study. The control group gained more weight during the study than the groups administered ITRAFUNGOL. The U.S. Food and Drug Administration (FDA) recently approved ITRAFUNGOL, an itraconazole oral solution for treating dermatophytosis caused by Microsporum canis in cats … 216-218 Oral formulations of 5 mg/kg were rapidly absorbed, the half‐life was approximately 15.6 h and bioavailablity was low (52%). ITRAFUNGOL has not been shown to be sporicidal; therefore in order to reduce zoonotic potential, environmental contamination, and to decrease course of the disease, topical and environmental treatment should also be utilized. This cat had repeated episodes of inappetence during the second and third dosing cycles. ITRAFUNGOL oral solution is a yellow to slightly amber, clear solution containing the active ingredient, itraconazole, at 10 mg/mL. Please check your email, and use the link to login in.To create your account, please enter your email and choose your password. Each line on the dosing syringe represents 0.05 mL of oral solution. Itrafungol is an oral, itraconazole solution just for cats.
This cat also had markedly elevated ALT and AST values on Day 36 (693 U/L and 283 U/L, respectively), was treated with minimal supportive care and recovered to complete the study. Oral Masses/Ulcers in Dogs and Cats. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or on line at www.fda.gov/reportanimalae It works by stopping the growth of fungi. Wash hands and exposed skin after use. One cat in group 4 (5X; Cat #26302) lost 22% of its body weight and had a number of episodes of vomiting, salivation, and anorexia during the treatment period. Itraconazole solution is used to treat fungal infections in the mouth and throat. We'll then ask you about your pets!You’ve indicated that this product is for multiple pets. ITRAFUNGOL (itraconazole oral solution) is available in a glass bottle containing 52 mL of oral solution, closed with a child resistant screw cap and packaged in a cardboard box that includes a package insert and a graduated dosing syringe. Treatment was successful in 238 (30.8 per cent) cats… The hydroxy-itraconazole remains near or below the quantification limit in feline plasma after a single dose of itraconazole oral solution at 5 mg/kg. In a study of 16 pregnant queens administered itraconazole oral solution at 5 mg/kg bodyweight for a total of 21 days (7 days on alternate weeks) during gestation or lactation, there was a high frequency of fetal resorption (partial and total), abnormal fetuses, and abnormal maternal behaviors.
Three independent studies evaluated the pharmacokinetics of itraconazole in healthy cats, although none used the currently licensed formulation for cats. Praziquantel Drocit Tapeworm 0.05 ml inj., 2.5 mg oral Treat once. Orthodontics for Pets. Four weeks after the end of treatment, 175 (83%) out of 207 cats treated with itraconazole oral solution were clinically cured. Compared to the fasted state, administration of ITRAFUNGOL with food results in slightly higher (1.3 fold) mean total itraconazole exposure (AUC), delay in median TIn cats, a single oral dose of 5 mg/kg results in a CIn the therapeutic treatment schedule, itraconazole is almost completely cleared from plasma after each wash-out period. Itraconazole is prescribed as an oral capsule, but other formulations are available, including oral suspension, ophthalmic solution, and topical applications. Of the 266 cats that received at least one dose of itraconazole oral solution, adverse reactions included 35 cases (13%) of one or more elevated hepatic enzymes and 8 cases (3%) of gastrointestinal upset, including decreased appetite, vomiting and/or diarrhea. In case of accidental ingestion, rinse mouth with water and seek medical advice. Food consumption was consistently higher throughout the study in the control group than the ITRAFUNGOL group. Mild gingival bleeding and perioral irritation (patchy alopecia and erythema) was noted in cats in the 3X and 5X groups.