Minimal oxidative metabolism (a phase I reaction) has been observed in all species evaluated.In humans, Ezetimibe is rapidly metabolized to Ezetimibe-glucuronide. Corresponding incidence rates for cholecystectomy were 0.6% (95% CI: 0%, 3.1%) and 1.7% (95% CI: 0.6%, 4%) for fenofibrate monotherapy and Ezetimibe coadministered with fenofibrate, respectively Because the reactions below are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.The following additional adverse reactions have been identified during post-approval use of Ezetimibe:Hypersensitivity reactions, including anaphylaxis, angioedema, rash, and urticaria; erythema multiforme; arthralgia; myalgia; elevated creatine phosphokinase; myopathy/rhabdomyolysis Caution should be exercised when using Ezetimibe and cyclosporine concomitantly due to increased exposure to both Ezetimibe and cyclosporine. Vous trouverez une description de chacun des objectifs sur la façon dont nos partenaires et nous-mêmes utilisons vos données personnelles.Vos préférences de navigation ont bien été enregitréesLe service d'authentification et de création de compte est momentanément indisponible. If you have any questions about Ezetimibe tablets, ask your doctor.
Incidence rates (95% CI) for clinically important elevations (≥3 × ULN, consecutive) in hepatic transaminase levels were 4.5% (1.9, 8.8) and 2.7% (1.2, 5.4) for fenofibrate monotherapy (n=188) and Ezetimibe co-administered with fenofibrate (n=183), respectively, adjusted for treatment exposure.
Should an increase in ALT or AST ≥3 × ULN persist, consider withdrawal of Ezetimibe and/or the statin.In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with Ezetimibe compared with the relevant control arm (placebo or statin alone). Only your doctor can determine if Ezetimibe tablets are right for you.Ezetimibe tablets are medicines used to lower levels of total cholesterol and LDL (bad) cholesterol in the blood.
Its mechanism of action results in a synergistic cholesterol-lowering effect together with a statin that inhibits cholesterol synthesis by the liver, which leads to the development of a fixed ezetimibe-simvastatin combination (Inegy).
Patients were randomized to receive placebo, Ezetimibe alone, 160-mg fenofibrate alone, or Ezetimibe and 160-mg fenofibrate in the 12-week study. In rats, increased incidences of common fetal skeletal findings (extra pair of thoracic ribs, unossified cervical vertebral centra, shortened ribs) were observed at 1000 mg/kg/day (~10 × the human exposure at 10 mg daily based on AUC Multiple-dose studies of Ezetimibe given in combination with statins in rats and rabbits during organogenesis result in higher Ezetimibe and statin exposures. In a 2-week clinical study in 18 hypercholesterolemic patients, Ezetimibe inhibited intestinal cholesterol absorption by 54%, compared with placebo. Ezetimibe (Ezetrol) selectively inhibits the intestinal absorption of cholesterol and phytosterols. Ezetimibe tablets are for patients who cannot control their cholesterol levels by diet and exercise alone. Protect from moisture.Patients should be advised to adhere to their National Cholesterol Education Program (NCEP)-recommended diet, a regular exercise program, and periodic testing of a fasting lipid panel.All patients starting therapy with Ezetimibe should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, tenderness or weakness. However, myopathy and rhabdomyolysis are known adverse reactions to statins and other lipid-lowering drugs. After a single 10-mg dose of Ezetimibe to fasted adults, mean Ezetimibe peak plasma concentrations (C Concomitant food administration (high-fat or non-fat meals) had no effect on the extent of absorption of Ezetimibe when administered as Ezetimibe 10-mg tablets. [See USP Controlled Room Temperature.] Ces cookies permettent d’interagir depuis le site Le Vidal avec les modules sociaux et de partager les contenus du site du avec d’autres personnes, lorsque vous cliquez sur le module "Partager", de Facebook et de Twitter, par exemple.