The occurrence of each outcome in patients taking azithromycin plus a statin was compared with patients taking clarithromycin or erythromycin plus a statin. Doch Antibiotika bergen, auch wenn sie nur kurzfristig eingenommen werden, mitunter ein hohes Wechselwirkungspotential. Also, they reported 53 cases that involved azithromycin and statins, mostly simvastatin. The inhibitory effect of different macrolides on OATP1B1/1B3 transporters was evaluated in an in vitro model, the IC50 for each macrolide against OATP1B1 was 96 µM (clarithromycin), 121 µM (telithromycin), 153 µM (roxithromycin), and 217 µM (erythromycin). More than 90% of the renal clearance of pravastatin and rosuvastatin is mediated by OAT3 transporter which is responsible for their active removal from circulation.Assuming that macrolides inhibit the metabolism/clearance of statins, this may lead to increased patient exposure to statins. In line, a cohort study found concurrent use of clarithromycin and CYP3A4-metabolized statins to be associated with a doubled risk of hospitalization with rhabdomyolysis or other statin-related adverse events as compared with azithromycin-statin co-administration. Azithromycin has previously been reported to increase the bioavailability of ivermectin, a substrate for the transporter P‐glycoprotein and CYP3A4 39 . So ist beispielsweise die Interaktion zwischen Statinen und Makrolid-Antibiotika in vielen Fällen relevant.Zu den Makrolid- bzw. Among the macrolide antibiotics, azithromycin has the least risk of adverse events when co-administered with statins (12).